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“哈靈生物”產品文獻:Science of The Total Environment

 Science of The Total Environment

Volumes 622–623, 1 May 2018, Pages 214-221
 
Developmental and metabolic responses of zebrafish (Danio rerio) embryos and 
 
larvae to short-chain chlorinated paraffins (SCCPs) exposure
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panelXiaoqianRenabHaijunZhangaNingboGengaLiguoXingcYuZhaocFeidiWangabJipingChe
 
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https://doi.org/10.1016/j.scitotenv.2017.11.304Get rights and content
Highlights
Effects of SCCPs on development and metabolism of zebrafish were evaluated.
 
SCCPs were highly toxic to zebrafish larvae, with 13-day LC50 value of 34.4 
 
μg/L.
 
Low-dose SCCPs slightly disturbed the overall metabolism in zebrafish embryos.
 
SCCPs mainly disturbed metabolisms of glycerophospholipids, fatty acids and 
 
purine.
 
 
Abstract
Short-chain chlorinated paraffins (SCCPs) are highly toxic to aquatic 
 
organisms, but their toxicity is yet not well characterized. In this study, 
 
the developmental toxicity of SCCPs to zebrafish embryos/larvae was evaluated, 
 
and a metabolomics approach was adopted to explore the impact of SCCPs 
 
exposure on the metabolism in zebrafish embryos. Exposure to SCCPs at 
 
concentrations of 1–200 μg/L did not produce an observable effect on the 
 
hatching rate and morphological deformities of zebrafish embryos/larvae. 
 
However, the survival rate of zebrafish larvae in SCCPs exposure groups 
 
decreased in a concentration-dependent manner. The 13-day 50% lethal 
 
concentration (LC50) value of SCCPs was calculated to be 34.4 μg/L. Exposure 
 
to SCCPs induced a significant change of overall metabolism, even at 
 
environmentally relevant concentrations (1–5 μg/L). The most relevant 
 
pathways affected by SCCPs exposure were glycerophospholipid metabolism, fatty 
 
acid metabolism and purine metabolism. Exposure to SCCPs at concentrations of 
 
1–5 μg/L had begun to accelerate the β-oxidation of unsaturated fatty acids 
 
and very long chain fatty acids, and affect the transformation of guanine to 
 
xanthine in the pathway of purine metabolism. Furthermore, when the exposure 
 
concentrations of SCCPs were increased to 50–200 μg/L, the levels of 
 
phospholipids and amino acids were significantly raised; whereas the levels of 
 
fatty acids, carnitines and inosine were significantly decreased. In view of 
 
the significant effect on metabolism, the sub-chronic and chronic toxicity of 
 
SCCPs to fish should be concerned.
 
Graphical abstract
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Keywords
Short-chain chlorinated paraffinsZebrafish 
 
embryo/larvaeMetabolomicsDevelopmental toxicity
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